* = equal contribution

  1. Protocol to measure contraction, calcium, and action potential in human-induced pluripotent stem cell-derived cardiomyocytes. Joe Z. Zhang, Shane Rui Zhao, Chengyi Tu, Paul Pang, Mao Zhang, Joseph C. Wu. STAR Protocols (2021).

  2. DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells. Yongjun Wang, Dong Han, Tingwen Zhou, Cheng Chen, Hong Cao, Joe Z Zhang, Ning Ma, Chun Liu, Moshi Song, Jiawei Shi, Xin Jin, Feng Cao, Nianguo Dong. European Heart Journal (2021).

  3. Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death. Xiaowei Zhong, Wenting Guo, Jinhong Wei, Yijun Tang, Yingjie Liu, Joe Z Zhang, Vern Hsen Tan, Lin Zhang, Ruiwu Wang, Peter P Jones, Carlo Napolitano, Silvia G Priori, S R Wayne Chen. Bioscience Reports (2021).

  4. Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies. Chour T, Tian L, Lau E, Thomas D, Itzhaki I, Malak O, Zhang JZ, Qin XL, Wardak M, Liu YG, Chandy M, Black KE, Lam MP, Neofytou E,  Wu JC. JCI Insight (2021).

  5. Effect of Cryopreservation on Human iPSC-Derived Cardiomyocytes for Assessing Drug Safety Response Profiles. Zhang JZ*, Belbachir N*, Zhang T*, Liu Y, Shrestha R, Wu JC. Stem Cell Reports (2021).

  6. Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy. Sayed N, Liu C, Ameen M, Himmati F, Zhang JZ, Khanamiri S, Moonen JR, Wnorowski A, Cheng LL, Rhee JW, Gaddam S, Wang K, Sallam K, Boyd JH, Woo YJ, Rabinovitch M, Wu JC. Science Translational Medicine (2020).

  7. RNA Sequencing Analysis of Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Congenital Heart Disease Patients. Kitani T, Tian L, Zhang T, Itzhaki I, Zhang JZ, Ma N, Liu C, Rhee JW, Romfh A, Lui GK, Wu JC. Circulation Research (2020).

  8. Modeling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. Wu H, Yang HX, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Blau HM, Bers DM, Wu JC. European Heart Journal (2019).

  9. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC. Cell Stem Cell (2019).​

  10. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Lee J, Termglinchan V, Diecke S, Itzhaki, I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC. Nature (2019).

  11. Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients. Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC. Circulation (2019).

  12. Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development. Guo H, Tian L, Zhang JZ, Kitani T, Paik DT, Lee WH, W JC. Stem cell Reports (2019).

  13. Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human Induced Pluripotent Stem Cells. Ma N*, Zhang JZ*, Itzhaki I*, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC. Circulation (2018).

  14. Applications of genetically engineered human pluripotent stem cell reporters in cardiac stem cell biology. Zhang JZ, Guo HC, Wu JC. Current Opinion in Biotechnology (2018).

  15. Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid. Liu Q, Van Bortle K, Zhang Y, Zhao MT, Zhang JZ, Geller BS, Gruber JJ, Jiang C, Wu JC, Snyder MP. Scientific Reports (2018).

  16. Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmström A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC. Stem Cell Reports (2018).

  17. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Zhao MT, Chen H, Liu Q, Shao NY, Sayed N, Wo HT, Zhang JZ, Ong SG, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez NM, Karakikes I, Mitalipov S, Snyder MP, Wu JC. Proceedings of the National Academy of Sciences (2017).

  18. FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2. Zhang JZ, Waddell HM, Wu E, Dholakia J, Okolo CA, McLay JC, Jones PP. Biochemical Journal (2016).

  19. Oxidation of RyR2 has a Biphasic Effect on the Threshold for SOICR. Waddell HMM, Zhang JZ, Hoeksema KJ, McLachlan JJ, McLay JC, Jones PP. Biophysical Journal (2016).

  20. Regulation of RyR2 by Sarcoplasmic Reticulum Ca2+. Zhang JZ, Waddell HMM & Jones PP. Clinical and Experimental Pharmacology and Physiology (2015).

  21. Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+ Release Activation and Termination. Liu Y, Sun B, Xiao Z, Wang R, Guo W, Zhang JZ, Mi T, Wang Y, Jones PP, Van Petegem F, Chen SR. Journal of Biological Chemistry (2015).

  22. Role of Cysteine3602 in the Function and Regulation of the Cardiac Ryanodine Receptor. Mi T, Xiao Z, Guo W, Tang Y, Hiess F, Xiao J, Wang Y, Zhang JZ, Zhang L, Wang R, Jones PP, Chen SR. Biochemical Journal (2015).

  23. The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+. Zhang JZ, McLay JC & Jones PP. Journal of Molecular and Cellular Cardiology (2014).