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Publications

* = equal contribution #=corresponding author

2020-2025
  1. Zeng, Q., Y. Yang, H. Wang, T. Ye, Z. Wang, M. Chai, Z. Lu, S. He, H. Yang, J. Z. Zhang# and X. Shi# (2026). "3D printing of structural bionic and functionalized hydrogels for the construction of macroscale human cardiac tissues." Biomaterials 325: 123573.

  2. Li, H., X. Wang, Y. Zhang, Y. Yang, J. Z. Zhang and B. Zhou (2025). "SLC39A13 Regulates Heart Function via Mitochondrial Iron Homeostasis Maintenance." Circ Res 137: e144-e156.

  3. Zhang, Y., H. Yang, Y. Yang, Z. Lu, L. Cheng, H. Tan and J. Z. Zhang# (2025). "Protocol for high-efficiency generation of iPSCs stably expressing Cas9-EGFP using the selection by essential gene exon knockin method." STAR Protoc 6(3): 103928.

  4. Zhang, Y., Z. Lu, H. Yang, L. Cheng, E. Zaklyazminskaya, O. Sokolova, H. Tan and J. Z. Zhang# (2025). "Generation of stable Cas9-EGFP expressing human induced pluripotent stem cell lines based on SeLection by Essential-gene Exon Knock-in technology." Stem Cell Research 85: 103710.

  5. Kiskin, F. N., Y. Yang, H. Yang and J. Z. Zhang# (2024). "Cracking the code of the cardiovascular enigma: hPSC-derived endothelial cells unveil the secrets of endothelial dysfunction." J. Mol. Cell. Cardiol. 192: 65-78.

  6. Yang, Y., H. Yang, F. N. Kiskin and J. Z. Zhang# (2024). "The new era of cardiovascular research: revolutionizing cardiovascular research with 3D models in a dish." Medical Review 4(1): 68-85.

  7. Yang, H., Y. Yang, Z. Lu and J. Z. Zhang# (2024). "Simultaneous Optical Imaging of Action Potentials and Calcium Transients in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes." Curr Protoc 4(7): e1101.

  8. Ji, X., Z. Chen, Q. Wang, B. Li, Y. Wei, Y. Li, J. Lin, W. Cheng, Y. Guo, S. Wu, L. Mao, Y. Xiang, T. Lan, S. Gu, M. Wei, J. Z. Zhang, L. Jiang, J. Wang, J. Xu and N. Cao (2024). "Sphingolipid metabolism controls mammalian heart regeneration." Cell Metabolism 36(4): 839-856.e838.

  9. Yang, H., Y. Yang, F. N. Kiskin, M. Shen and J. Z. Zhang# (2023). "Recent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes." Stem Cell Research & Therapy 14(1): 228.

  10. Liu, C., M. Shen, Y. Liu, A. Manhas, S. R. Zhao, M. Zhang, N. Belbachir, L. Ren, J. Z. Zhang, A. Caudal, M. Nishiga, D. Thomas, A. Zhang, H. Yang, Y. Zhou, M. Ameen, N. Sayed, J.-W. Rhee, L. S. Qi and J. C. Wu (2024). "CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity." Cell Stem Cell 31(12): P1760-P1776.

  11. Ye, S., C. Wang, Z. Xu, H. Lin, X. Wan, Y. Yu, S. Adhicary, J. Z. Zhang, Y. Zhou, C. Liu, M. Alonzo, J. Bi, A. Ramirez-Navarro, I. Deschenes, Q. Ma, V. Garg, J. C. Wu and M. T. Zhao (2023). "Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency." Circ Res 132(2): 187-204.

  12. Belbachir, N., Y. Wu, M. Shen, S. L. Zhang, J. Z. Zhang, C. Liu, B. C. Knollmann, G. J. Lyon, N. Ma and J. C. Wu (2023). "Studying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells." Circulation 148(20): 1598-1601.

  13. Eguchi, A., A. Gonzalez, S. I. Torres-Bigio, K. Koleckar, F. Birnbaum, J. Z. Zhang, V. Y. Wang, J. C. Wu, S. E. Artandi and H. M. Blau (2023). "TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs." Proc Natl Acad Sci U S A 120(6): e2209967120.

  14. Chour, T., L. Tian, E. Lau, D. Thomas, I. Itzhaki, O. Malak, J. Z. Zhang, X. Qin, M. Wardak, Y. Liu, M. Chandy, K. E. Black, M. P. Lam, E. Neofytou and J. C. Wu (2021). "Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies." JCI Insight 6(7).

  15. Wang, Y., D. Han, T. Zhou, C. Chen, H. Cao, J. Z. Zhang, N. Ma, C. Liu, M. Song, J. Shi, X. Jin, F. Cao and N. Dong (2021). "DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells." Eur Heart J 42(30): 2935-2951.

  16. Zhang, J. Z*., N. Belbachir*, T. Zhang*, Y. Liu, R. Shrestha and J. C. Wu (2021). "Effects of Cryopreservation on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Assessing Drug Safety Response Profiles." Stem Cell Reports 16(1): 168-181.

  17. Zhang, J. Z#., S. R. Zhao, C. Tu, P. Pang, M. Zhang and J. C. Wu# (2021). "Protocol to measure contraction, calcium, and action potential in human-induced pluripotent stem cell-derived cardiomyocytes." STAR Protoc 2(4): 100859.

  18. Zhong, X., W. Guo, J. Wei, Y. Tang, Y. Liu, J. Z. Zhang, V. H. Tan, L. Zhang, R. Wang, P. P. Jones, C. Napolitano, S. G. Priori and S. R. W. Chen (2021). "Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death." Biosci Rep 41(4).

  19. Sayed, N., C. Liu, M. Ameen, F. Himmati, J. Z. Zhang, S. Khanamiri, J. R. Moonen, A. Wnorowski, L. Cheng, J. W. Rhee, S. Gaddam, K. C. Wang, K. Sallam, J. H. Boyd, Y. J. Woo, M. Rabinovitch and J. C. Wu (2020). "Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy." Sci Transl Med 12(554): eaax9276.

  20. Kitani, T., L. Tian, T. Zhang, I. Itzhaki, J. Z. Zhang, N. Ma, C. Liu, J. W. Rhee, A. W. Romfh, G. K. Lui and J. C. Wu (2020). "RNA Sequencing Analysis of Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Congenital Heart Disease Patients." Circ Res 126(7): 923-925.

  1. Guo, H., L. Tian, J. Z. Zhang, T. Kitani, D. T. Paik, W. H. Lee and J. C. Wu (2019). "Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development." Stem Cell Reports 12(4): 772-786.

  2. Lee, J., V. Termglinchan, S. Diecke, I. Itzhaki, C. K. Lam, P. Garg, E. Lau, M. Greenhaw, T. Seeger, H. Wu, J. Z. Zhang, X. Chen, I. P. Gil, M. Ameen, K. Sallam, J. W. Rhee, J. M. Churko, R. Chaudhary, T. Chour, P. J. Wang, M. P. Snyder, H. Y. Chang, I. Karakikes and J. C. Wu (2019). "Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy." Nature 572(7769): 335-340.

  3. Wu, H., H. Yang, J. W. Rhee, J. Z. Zhang, C. K. Lam, K. Sallam, A. C. Y. Chang, N. Ma, J. Lee, H. Zhang, H. M. Blau, D. M. Bers and J. C. Wu (2019). "Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients." Eur Heart J 40(45): 3685-3695.

  4. Kitani, T., S. G. Ong, C. K. Lam, J. W. Rhee, J. Z. Zhang, A. Oikonomopoulos, N. Ma, L. Tian, J. Lee, M. L. Telli, R. M. Witteles, A. Sharma, N. Sayed and J. C. Wu (2019). "Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer." Circulation 139(21): 2451-2465.

  5. Zhang, J. Z., V. Termglinchan, N. Y. Shao, I. Itzhaki, C. Liu, N. Ma, L. Tian, V. Y. Wang, A. C. Y. Chang, H. Guo, T. Kitani, H. Wu, C. K. Lam, K. Kodo, N. Sayed, H. M. Blau and J. C. Wu (2019). "A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles." Cell Stem Cell 24(5): 802-811 e805.

  6. Zhao, X., H. Chen, D. Xiao, H. Yang, I. Itzhaki, X. Qin, T. Chour, A. Aguirre, K. Lehmann, Y. Kim, P. Shukla, A. Holmstrom, J. Z. Zhang, Y. Zhuge, B. C. Ndoye, M. Zhao, E. Neofytou, W. H. Zimmermann, M. Jain and J. C. Wu (2018). "Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction." Stem Cell Reports 10(2): 422-435.

  7. Liu, Q., K. Van Bortle, Y. Zhang, M. T. Zhao, J. Z. Zhang, B. S. Geller, J. J. Gruber, C. Jiang, J. C. Wu and M. P. Snyder (2018). "Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid." Sci Rep 8(1): 12960.

  8. Ma, N*., J. Z. Zhang*, I. Itzhaki*, S. L. Zhang, H. Chen, F. Haddad, T. Kitani, K. D. Wilson, L. Tian, R. Shrestha, H. Wu, C. K. Lam, N. Sayed and J. C. Wu (2018). "Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells." Circulation 138(23): 2666-2681.

  9. Zhang, J. Z., H. Guo and J. C. Wu (2018). "Applications of genetically engineered human pluripotent stem cell reporters in cardiac stem cell biology." Curr Opin Biotechnol 52: 66-73.

  10. Zhao, M. T., H. Chen, Q. Liu, N. Y. Shao, N. Sayed, H. T. Wo, J. Z. Zhang, S. G. Ong, C. Liu, Y. Kim, H. Yang, T. Chour, H. Ma, N. M. Gutierrez, I. Karakikes, S. Mitalipov, M. P. Snyder and J. C. Wu (2017). "Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs." Proc Natl Acad Sci U S A 114(52): E11111-E11120.

  11. Waddell, H. M. M., J. Z. Zhang, K. J. Hoeksema, J. J. McLachlan, J. C. McLay and P. P. Jones (2016). "Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release." Biophys J 110(11): 2386-2396.

  12. Zhang, J. Z., H. M. Waddell, E. Wu, J. Dholakia, C. A. Okolo, J. C. McLay and P. P. Jones (2016). "FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2." Biochem J 473(14): 2049-2060.

  13. Zhang, J. Z., H. M. Waddell and P. P. Jones (2015). "Regulation of RYR2 by sarcoplasmic reticulum Ca(2+)." Clin Exp Pharmacol Physiol 42(6): 720-726.

  14. Mi, T., Z. Xiao, W. Guo, Y. Tang, F. Hiess, J. Xiao, Y. Wang, J. Z. Zhang, L. Zhang, R. Wang, P. P. Jones and S. R. Chen (2015). "Role of Cys³⁶⁰² in the function and regulation of the cardiac ryanodine receptor." Biochem J 467(1): 177-190.

  15. Liu, Y., B. Sun, Z. Xiao, R. Wang, W. Guo, J. Z. Zhang, T. Mi, Y. Wang, P. P. Jones, F. Van Petegem and S. R. Chen (2015). "Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination." J Biol Chem 290(12): 7736-7746.

  16. Zhang, J. Z., J. C. McLay and P. P. Jones (2014). "The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca2+ release due to an impaired ability to buffer store Ca2+." J. Mol. Cell. Cardiol. 74: 22-31.

2014-2019

Joe Zhang Lab @ Shenzhen Bay Laboratory
Address: Weiguang Life Sciences Park, Guangming district,
Shenzhen, Guangdong Province, China
https://www.szbl.ac.cn/

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