The heart is a complex organ composed of several cell types. Studies have shown that interactions between cardiomyocytes and other cells play an important role in maintaining the homeostasis of the heart and remodeling the heart under pathological conditions. One of the ongoing projects is to decipher the mechanisms underlying cardiac fibrosis in hypertrophic cardiomyopathy. We are also actively exploring the cross-talk between cardiomyocytes and other cell types using state-of-the-art technologies to better understand how different cell types contribute to the development of heart diseases. The overarching goal is to understand the mechanism of heart diseases in a more precise manner and eventually lead to tailored therapeutic regimens.